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... News and Announcements

CMIF wins Nikon Small World Prize!

Ticks are external parasites. They are widely distributed around the world, especially in warm, humid environment. Ticks live by sucking the blood as their nutrition. Because of their blood-ingesting diets and infections caused by pathogens, ticks act as vectors of many serious diseases that affect humans and other animals.
Dr. Tong Zhang imaged this sample by taking the advantage of sample auto-fluorescence under different wavelengths with a 10x objective on a Nikon A1R Confocal Microscope at CMIF. There were 423 Z-direction images covering through a 211um thickness. Extended focus function re-built the 3D Z-stack images into a 2D image with 3D information. The microscope resonant scanner boosted the acquisition speed significantly.

This image had very fine details and striking looking. The auto-fluorescence revealed tick head’s anatomy and specially the mouth region with inverted-arrow-like structure. Ticks use this kind of structure to anchor them on animals. It is a good example of nature smart designs.

The Nikon Small World Competition first began in 1975 as a means to recognize and applaud the efforts of those involved with photography through the light microscope. Since then, its has become a leading showcase for photomicrographers from the widest array of scientific disciplines. This year is the 47th year of the competition, which had almost 1,900 images from 88 countries submitted for consideration.


Ticket Head
Tong Zhang, PhD and Paul Stoodley, PhD, Campus Microscopy & Imaging Facility (CMIF)
Winning the 7th Place in 2021 Nikon Small World Photomicrography Competition
To Nikon A1R Users:

The software has been updated on Feb. 5, 2021.

To make the software looking as similar as the old version and make sure all functions work properly, please note the new username/password are listed in Nikon A1R room.

Please watch this video (below) for the comparison between the old and new version software (Notice: this is only for the reference purpose, some details are not identical).

(YouTube - Created by University of Pittsburgh Center for Biologic Imaging)

We are working on a new version manual. It will be available to all users soon.

--CMIF, Feb. 9, 2021


On 1/7/2020 our scheduling system (FOM.osu.edu) that is used for making reservations for our instrumentation was integrated into Workday. All users will need to have a Workday requisition that has been entered into FOM.

For directions on how to create a requisition in Workday that will be used in FOM, please refer to this link - https://go.osu.edu/fomrequisition. Please make sure to select "CMIF - Campus Microscopy Imaging Facility" as the supplier.

Imaging Beyond the Diffraction Limit: Nikon N-SIM and N-STORM Super-resolution Systems coming to CMIF/MSR soon

Excuse the disruption as we remodel to house the system in the BRT268 BSL2 suite!

CMIF / OSUCCC MSR Training Policy Update

Training is an Important Mission of the CMIF / OSUCCCMSR!
Not only does it afford trainees the experience hands-on operation of sophisticated and expensive imaging systems but also has many other advantages. Intimate familiarity with our instrumentation allows users to explore aspects of imaging that they might not otherwise have considered and also brings down operating costs, a critical factor in budgeting research budgets. Working closely with experienced CMIF staff also allows trainees and our staff to mutually explore various approaches to experimental design, maximizing the quality and type of data afforded by our imaging systems. And of course generally a user that knows what they are looking for in a specimen according to the experimental design, which to a third party might not be so obvious.

Currently We Are Operating Under an OR approved Phase III Covid SOP
Which unfortunately due to social distancing restrictions, makes one-on-one training challenging. We have submitted a Phase IV SOP for one-on-one training when social distancing is impractical due to finer manipulations of specimens or instrumentation. Our SOP is under review and needs to be aligned with training protocols in the other OSU cores.

Interim Training Procedures
Meanwhile we have alternatives. Our trained staff can operate the instrumentation while the user observes – either at a distance (we have found that there is a surprising amount of co-ordination that can be accomplished by observing our screens at a 6’ distance and verbally communicating with our operating staff) or via zoom where a phone camera is set up to focus on the specimen, operating panel or the screen allowing real time communication between staff operator and the user.

Future Digital Remote Training Options
We are currently purchasing tripods for cell phones to allow such positioning. We are also working on putting together a library of training videos to cover some of the more basic aspects of each instrument. We will continue this effort even when the Covid restrictions are ended since these may replace the more basic one-on-one initial training, thus freeing up time for our staff to work with more users and give them more time to work on experimental design, methods development and equipment proposals.

We understand your frustration but please rest assured we are as keen to get back to training as much as you are! - Paul